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A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
It can grind a large variety of substances and, because it is closed system, even grinding of toxic products can be achieved (Sushant and Archana, 2013). Ball milling produces fine particles with
Wet chemistry is a form of analytical chemistry that uses classical methods such as observation to analyze materials. It is called wet chemistry since most analyzing is done in the liquid phase. Wet chemistry is also called bench chemistry since many tests are performed at lab benches.
Combining grinding and extraction by the use of hot water for wet grinding resulted in considerable losses of aroma compounds because of the prolonged heat impact. Therefore, a more promising twostep process involving cold wet grinding and subsequent hot extraction in a closed system was introduced.
The method of claim 1 wherein said method is a wet grinding process. 6. The method of claim While this invention is described herein in connection with its preferred utilities,, with respect to drug substances for use in pharmaceutical compositions and imaging agents for
Sep 01, 2010#0183;#32;Dry grinding of organic substances requires elaborate exhaust and filter fans that are meant to avert the danger of dust explosions. Wet grinding processes offer an efficient alternative and are able to achieve even very small particle sizes. Heavyduty dispersing machines such as the Dispax DR 2000 and DRS 2000 Reactors boast various advantages: closed []
METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES (PAT WO) CZEKAI David A., SEAMAN Larry P. EASTMAN KODAK COMPANY. Patent: the with report World Intellectual Property Organization. Application: WO1995US06035 on
Continuous method of grinding pharmaceutical substances . United States Patent . Abstract: A continuous method of Thus, the wet grinding process can be practiced in conjunction with a liquid dispersion medium and surface modifier such as described in these publications.
The method enables the use of fine grinding media,, of a particle size of less than about 300 ''mu''m, in a continuous grinding process which provides extremely fine particles of the agent,, particles less than 100 nm in size, while avoiding problems,, separator screen plugging, associated with prior art processes requiring the
A method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
Discuss; grinding Methods title claims abstract description 49; substances Substances title description 7; particles Substances
Wet milling with IKA''s inline machines is a safe and efficient alternative to dry grinding. Dry grinding creates a lot of dust which causes the need for proper filtering systems. This can be of particular importance during grinding of substances whose dust, when mixed with aerial oxygen, can result in explosive mixtures.
#0183;#32;Method of grinding pharmaceutical substances . European Patent EP . Kind Code: B1 . Abstract: A method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin.
Objective: The purpose of this study was to investigate the dissolution and oral bioavailability of an immediaterelease tablet involving wet grinding of a poorly watersoluble drug, fenofibrate. Methods: The milled suspension was prepared using a Basket Dispersing Mill in the presence of a hydrophilic polymer solution and then granulated with common excipients, and compressed into an
Nov 01, 2019#0183;#32;Among these methods, media milling is one of the most efficient ways to obtain submicron drug particles aiming to improve oral bioavailability . Wetmilling process is one of the well developed media milling processes, by which the drug(s) is milled in liquid normally containing hydrophilic polymer and/or surfactant stabilizer(s).
A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles,, less than 100 nanometers in size, free of unacceptable contamination.
Separation of substances using more than one method. A mixture of sand and salt can be separated by combination of methods. The first method is sedimentation and mixture is put in water and left for the sand to settle for some time. Then we will decant the salty water which will separate the sand from the mixture.
TiO2 particles are aggregates produced via a bottomup method, while CaCO3 are primary mineral particles produced by a topdown method. The most energy efficient grinding of TiO2 to a 300 nm
I have discovered a method of preparing stable, dispersible drug nanoparticles by providing drug particles, depyrogenating grinding media and mixing the drug particles and grinding media and autoclaving prior to adding a surface modifier and wet milling the drug substance sufficient to maintain an effective particle size of less than 400 nm.
METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES (PAT EP) CZEKAI David A., SEAMAN Larry P. NanoSystems Patent: Publ. of Application with search report European Patent Office. Application: EP on Publication: . Abstract: Highlight Terms
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Pharma amp; Cosmetics Pharma amp; Cosmetics Dispersing amp; Homogenizing Wet Grinding DeAerating Laboratory Machines NETZSCHBeads #174; Laboratory Tests Seminars Webinars Biotechnology Cosmetics / Personal Hygiene Pharmaceuticals Extremely small batches for Active Pharmaceutical Substances with the NETZSCH DeltaVita 1 it''s now possible!
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